April 23, 1935 White Sox 7, Tigers 2 (2-5)
At this early stage of the season, the Tigers were definitely not playing like the defending American League champs. At least the home crowd in Chicago got to see their team win on opening day.
Almost all of the damage happened in the fifth inning. The game was scoreless, and the White Sox had the bases loaded with two outs when rookie left fielder Chet Morgan misplayed a ball that led to two runs. With a walk and two singles after the error, the ultimate damage of the error ended up being five runs.